Matrixyl 3000, an effective ingredient in anti wrinkle cream To reduce wrinkle aging

Matrixyl 3000 is an ingredient in anti wrinkle cream formulations that has been proven to decrease the density of existing wrinkles, decrease their volume as well as decrease their depth. The compound contains the matrikines Palmitoyl Tetrapeptide -7 and Palmitoyl Oligopeptide.  Matrixyl 3000 stimulates the fibroblast cells and promotes the production of collages, thereby reducing the appearance of wrinkles significantly.  Fibroblasts continue to create collagen even in old age, but their levels decrease as a person ages, causing wrinkle, aging and dryness.

Recently, Matrixyl 3000 has been steadily gaining popularity as a wrinkle cream ingredient because of its effectiveness.  The matrikines Pal-GQPR and Pal-GHK acts in synergy so that the damages caused by age are repaired.  Matrixyl 3000 activates the body’s natural production of elastin, collagen and hyaluronic acid, reducing the signs of aging including little lines and wrinkles.  Collagen, the amino acids responsible for the skin’s youthful look and smoothness progressively gets lost as the individual ages, wrinkle aging skin replacing the young skin. Collagen breaks down into smaller chains called peptides, which signals the skin to produce more collagen. The peptides are mimicked by Matrixyl 3000, making the body think that more collagen as well as elastin and hyaluronic acid are needed by the skin.

Classic Matrixyl was developed by Sederma Corporation and formulated Matrixyl 3000 as the improved new version of the classic skincare ingredient.  They are both available in the market and are incorporated separately in different skin care, wrinkle cream and anti-aging products.  Both formulas are based on peptides and designed to stimulate the replenishment of the structural framework of the skin.  Matrixyl 3000 contains two peptides while the original Matrixyl is the name for palmitoyl pentapeptide-4. 

One of the two active components of Matrixyl 3000, Palmitoyl oligopeptide (Pal-GHK) is a peptide believed to indicate the degradation of the matrix of the skin.  When fibroblasts, the cells that produce the skin matrix detect higher levels of GHK, they synthesize more skin matrix assuming that they are being lost faster.  Pal-GHK is a more advanced version of GHK because it penetrates the skin better so it can stimulate the replenishment of the skin matrix through topical application.  Wrinkle, aging and small lines are visibly reduced and the skin gets firmer and smoother.

The other active component of Matrixyl 3000 is Palmitoyl tetrapeptide-7 (Pal-GQPR) is known to reduce the skin cells’ production of interleukin-6 (IL-6).  The molecule known as IL-6 is known to promote inflammation and thus contribute to the skin matrix degradation.  This results in the loss of skin elasticity and firmness and the development of little lines and wrinkles.  As wrinkle cream ingredient, Matrixyl 3000 helps in stimulating the replenishment of the skin matrix and slows down its degradation. 

Ageless Derma Skincare and Anti-aging products incorporate the properties of palmitoyl tetrapeptide-7 and palmitoyl oligopeptide to help slow down the effect of skin matrix degradation and stimulate the natural production of hyaluronic acid, elastin and collagen. The combination of the two peptides results in better synergy instead of just one.  They support each other’s properties for maximum and dramatic effect. Continued use of Ageless Derma anti-aging products with Matrixyl 3000 keeps the skin healthy looking and youthful, preventing wrinkle, aging and skin degradation.

Matrixyl 3000 concentration in formulas used for human study conducted by Sedema was 3%.  The manufacturer recommends a range of concentration for wrinkle cream formulations from 3% to 8%.  Data showed that the maximum effect produced by Matrixyl appear at 10-15 ppm concentration. The substance also appeared to be free of adverse side effects according to short-term study.  There are still no reports of side effects for long-term use. Matrixyl can also be used for DIY winkle cream formulas as it can be purchased as a stock solution and can be combined with many other actives and vehicles.  The opalescent gel raw substance should be incorporated at cool down, when the formulation is below 40C.  It is soluble in water and recommended long term storage is at 39.2°F (4°C).  

Matrikine is a word referring to fragmented matrix peptides.  The anti-aging product Matrixyl 3000 from Sederma is composed of two matrikines with the ability to regulate the activities of cells.  Palmitoyl oligopeptide and palmitoyl tetrapeptide-7 are the two peptides contained in Matrix 3000, which acts to repair and restructure the dermis.  The synergestic action of the two peptides effectively maintains and restores the youthful appearance of the skin.  Matrixyl 3000 is now being widely used as an ingredient in wrinkle cream and anti-aging products in the form of serums, creams, lotions and gels.